{"id":146,"date":"2022-04-06T09:54:00","date_gmt":"2022-04-06T07:54:00","guid":{"rendered":"http:\/\/blog.cell-lavie.com\/?p=146"},"modified":"2026-09-03T12:39:38","modified_gmt":"2026-09-03T12:39:38","slug":"stem-cell-treatment-may-have-cured-woman-of-hiv","status":"publish","type":"post","link":"https:\/\/cell-lavie.com\/fr\/blog\/2022\/04\/06\/stem-cell-treatment-may-have-cured-woman-of-hiv\/","title":{"rendered":"Le traitement par cellules souches pourrait avoir gu\u00e9ri une femme du VIH"},"content":{"rendered":"<ul class=\"wp-block-list\"><li><strong>Une femme s\u00e9ropositive qui a re\u00e7u une greffe de cellules souches sanguines pour traiter une leuc\u00e9mie my\u00e9lo\u00efde aigu\u00eb semble avoir \u00e9t\u00e9 gu\u00e9rie du VIH.<\/strong><\/li><li><strong>Les cellules souches, provenant du sang du cordon ombilical, contenaient une variante g\u00e9n\u00e9tique qui les rend r\u00e9sistantes \u00e0 l&#039;infection par le VIH.<\/strong><\/li><li><strong>La femme n&#039;a plus contract\u00e9 le VIH depuis 14 mois depuis le traitement.<\/strong><\/li><li><strong>Cette d\u00e9couverte pourrait pointer vers un rem\u00e8de contre le VIH pour certains patients.<\/strong><\/li><\/ul>\n\n\n<p class=\"wp-block-paragraph\">Une femme d&#039;\u00e2ge moyen, m\u00e9tisse et s\u00e9ropositive n&#039;a plus le virus depuis qu&#039;elle a re\u00e7u une greffe de cellules souches sanguines pour une autre maladie.<\/p>\n\n\n<!--more-->\n\n\n<p class=\"wp-block-paragraph\">Apr\u00e8s une chimioth\u00e9rapie \u00e0 haute dose pour\u00a0<a href=\"https:\/\/www.medicalnewstoday.com\/articles\/215538\">leuc\u00e9mie aigu\u00eb my\u00e9lo\u00efde<\/a>\u00a0\u2014 un traitement qui d\u00e9truit les cellules sanguines \u2014 la femme a re\u00e7u la greffe de cellules souches de sp\u00e9cialistes \u00e0\u00a0<a rel=\"noreferrer noopener\" href=\"https:\/\/weill.cornell.edu\/\" target=\"_blank\">M\u00e9decine Weill Cornell<\/a>, a New York.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Ils ont utilis\u00e9 des cellules de greffe provenant de deux sources : des cellules souches d&#039;un parent adulte en bonne sant\u00e9 et du sang de cordon ombilical d&#039;un nouveau-n\u00e9 non apparent\u00e9.&nbsp;<\/p>\n\n\n<p class=\"wp-block-paragraph\">Les m\u00e9decins utilisent le sang du cordon ombilical pour fournir des cellules souches sanguines lorsqu&#039;une bonne correspondance ne peut \u00eatre trouv\u00e9e. Les cellules souches du cordon r\u00e9ussissent souvent, m\u00eame lorsque leurs marqueurs immunitaires ne correspondent que partiellement \u00e0 ceux du receveur.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Les cellules souches du donneur adulte sont utilis\u00e9es pour restaurer rapidement la population de cellules sanguines du patient. Les cellules souches du cordon se r\u00e9pliquent pour reconstituer les cellules sanguines \u00e0 plus long terme.<\/p>\n\n\n<p class=\"wp-block-paragraph\">Pour cette greffe, les m\u00e9decins ont utilis\u00e9 des cellules souches du sang ombilical contenant une variante du g\u00e8ne qui conf\u00e8re une r\u00e9sistance au VIH. La\u00a0<em>CCR5<\/em>\u00a0code un r\u00e9cepteur cellulaire utilis\u00e9 par le virus du VIH pour p\u00e9n\u00e9trer dans les cellules, mais le\u00a0<em>CCR5\u039432<\/em>\u00a0variante bloque l&#039;entr\u00e9e du virus.<\/p>\n\n\n<h2 class=\"wp-block-heading\"><a>Disparition du VIH<\/a><\/h2>\n\n\n<p class=\"wp-block-paragraph\">Trois mois apr\u00e8s le traitement, les m\u00e9decins ont constat\u00e9 que toutes les cellules sanguines du patient provenaient des cellules souches du sang de cordon r\u00e9sistantes au VIH. L&#039;\u00e9quipe n&#039;a d\u00e9tect\u00e9 aucun VIH lors d&#039;analyses tr\u00e8s sensibles du sang du patient.<\/p>\n\n\n<p class=\"wp-block-paragraph\">La patiente a alors cess\u00e9 de prendre des m\u00e9dicaments antir\u00e9troviraux pour supprimer son infection par le VIH.&nbsp;<\/p>\n\n\n<p class=\"wp-block-paragraph\"><strong>Aujourd&#039;hui, 14 mois apr\u00e8s le traitement, l&#039;infection par le VIH n&#039;a pas r\u00e9apparu. Le patient est \u00e9galement sans leuc\u00e9mie depuis 4 ans.<\/strong><\/p>\n\n\n<p class=\"wp-block-paragraph\">source : Universit\u00e9 Weill Cornell <\/p>","protected":false},"excerpt":{"rendered":"<p>An HIV-positive woman who received a blood stem cell transplant to treat acute myeloid leukemia appears to have been cured of HIV. The stem cells, from umbilical cord blood, contained a gene variant that makes them resistant to HIV infection. The woman has been free of HIV for 14 months since the treatment. This finding [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[97,71],"tags":[81],"class_list":["post-146","post","type-post","status-publish","format-standard","hentry","category-hiv","category-stem-cells","tag-stem-cells"],"featured_image_src":{"landsacpe":false,"list":false,"medium":false,"full":false},"_links":{"self":[{"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/posts\/146","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/comments?post=146"}],"version-history":[{"count":1,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/posts\/146\/revisions"}],"predecessor-version":[{"id":619,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/posts\/146\/revisions\/619"}],"wp:attachment":[{"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/media?parent=146"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/categories?post=146"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/tags?post=146"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}