{"id":200328,"date":"2024-06-14T14:36:17","date_gmt":"2024-06-14T14:36:17","guid":{"rendered":"https:\/\/cell-lavie.com\/how-dab2ip-protein-slows-breast-cancer-growth-by-reducing-glucose-uptake\/"},"modified":"2026-09-03T12:15:02","modified_gmt":"2026-09-03T12:15:02","slug":"how-dab2ip-protein-slows-breast-cancer-growth-by-reducing-glucose-uptake","status":"publish","type":"post","link":"https:\/\/cell-lavie.com\/fr\/blog\/2024\/06\/14\/how-dab2ip-protein-slows-breast-cancer-growth-by-reducing-glucose-uptake\/","title":{"rendered":"How\u00a0DAB2IP Protein\u00a0Slows Breast\u00a0Cancer Growth\u00a0by Reducing Glucose\u00a0Uptake"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Breast cancer is one of the most common cancers worldwide. As tumors grow, they often face hypoxia &#8211; low oxygen conditions. Cancer cells adapt to hypoxia by increasing glucose uptake to fuel their rapid growth. A protein called HIF-1\u03b1 plays a key role in this process.<\/p>\n<p><!--more--><\/p>\n<p class=\"wp-block-paragraph\">A new study by Wang et al. published in Oncogenesis has uncovered how another protein called DAB2IP acts as a tumor suppressor in breast cancer by inhibiting glucose uptake under hypoxic conditions<a href=\"https:\/\/www.nature.com\/articles\/s41389-024-00523-4\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a>.\u00a0The researchers found that DAB2IP binds to HIF-1\u03b1 and promotes its degradation via ubiquitination. This reduces the ability of breast cancer cells to take up glucose in low oxygen environments.<\/p>\n<p class=\"wp-block-paragraph\">The team first analyzed human breast cancer databases and found that low DAB2IP expression correlated with worse patient survival. They then conducted experiments in breast cancer cell lines and mouse models with varying DAB2IP levels.Under hypoxic conditions, cells and tumors with low DAB2IP showed:<\/p>\n<ul class=\"wp-block-list\">\n<li>Increased HIF-1\u03b1 protein levels<\/li>\n<li>Higher glucose uptake<\/li>\n<li>Faster tumor growth<\/li>\n<\/ul>\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/media.springernature.com\/lw685\/springer-static\/image\/art%3A10.1038%2Fs41389-024-00523-4\/MediaObjects\/41389_2024_523_Fig1_HTML.png?ssl=1\" alt=\"DAB2IP acted as a tumor suppressor and was involved in glucose metabolism in breast cancer.\"\/><\/figure>\n<p class=\"wp-block-paragraph\">In contrast, overexpressing DAB2IP in breast cancer cells led to:<\/p>\n<ul class=\"wp-block-list\">\n<li>Decreased HIF-1\u03b1 due to increased ubiquitination and degradation<\/li>\n<li>Reduced glucose uptake<\/li>\n<li>Slower tumor growth in mice<\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\">The researchers propose that DAB2IP acts as a endogenous HIF-1\u03b1 inhibitor by facilitating its ubiquitination and subsequent breakdown, thus limiting hypoxia adaptation and glucose utilization by breast cancer cells. These findings highlight the important tumor suppressive function of DAB2IP and its potential as a therapeutic target in breast cancer.In summary, this study reveals a new mechanism by which DAB2IP protein helps restrain breast cancer growth and progression, by impairing the ability of tumor cells to take up glucose under hypoxic conditions. Increasing DAB2IP levels could be a promising strategy to slow down breast cancer and improve patient outcomes.<\/p>","protected":false},"excerpt":{"rendered":"<p>Breast cancer is one of the most common cancers worldwide. As tumors grow, they often face hypoxia &#8211; low oxygen conditions. Cancer cells adapt to hypoxia by increasing glucose uptake to fuel their rapid growth. A protein called HIF-1\u03b1 plays a key role in this process.<\/p>","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[71],"tags":[],"class_list":["post-200328","post","type-post","status-publish","format-standard","hentry","category-stem-cells"],"featured_image_src":{"landsacpe":false,"list":false,"medium":false,"full":false},"_links":{"self":[{"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/posts\/200328","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/comments?post=200328"}],"version-history":[{"count":1,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/posts\/200328\/revisions"}],"predecessor-version":[{"id":200954,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/posts\/200328\/revisions\/200954"}],"wp:attachment":[{"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/media?parent=200328"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/categories?post=200328"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cell-lavie.com\/fr\/wp-json\/wp\/v2\/tags?post=200328"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}