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Yorkie 通过 microRNA 介导的细胞衰老抑制来驱动 Ras 诱导的肿瘤进展

尽管激活 GTPase Ras 中的突变会促进癌症，但 Ras 也会诱导细胞衰老，这是 Ras 激活促进肿瘤进展所必需克服的障碍。使用 Ras 诱导的果蝇肿瘤生长模型，Ito 和 Igaki 发现 Ras 诱导的细胞衰老需要 ETS 家族转录因子 Pnt。上皮起源的癌症中经常发生的细胞极性缺失激活转录因子 Yki，导致一系列 microRNA 介导的调节事件，最终抑制 Pnt。考虑到大多数这些蛋白质的保守性及其调节关系，这种机制可能与细胞极性的丧失如何消除人类 Ras 诱导的肿瘤生长的抑制有关。

Jun 24, 2021

年龄相关性黄斑变性干细胞治疗的冰冻飞跃

Scientists at UC Santa Barbara, University of Southern California (USC), and the biotechnology company Regenerative Patch Technologies LLC (RPT) have reported new methodology for preservation of RPT's stem cell-based therapy for age-related macular degeneration (AMD).

Jun 22, 2021

干细胞如何同步修复蝾螈的脊髓

脊髓是我们中枢神经系统的重要组成部分：它将大脑与身体的其他部分连接起来，并在协调我们的感觉与我们的行动方面发挥着至关重要的作用。跌倒、暴力、疾病——各种形式的创伤都可能对脊髓造成不可逆转的损伤，导致瘫痪，有时甚至死亡。

Jun 20, 2021

工程自然杀伤细胞可以消除胶质母细胞瘤癌症干细胞

Deleting the TFG-β receptor in NK cells overcame immune suppression and enabled anti-tumor activity in preclinical models. Preclinical research from The University of Texas MD Anderson Cancer Center finds that although glioblastoma stem cells (GSCs) can be targeted by natural killer (NK) cells, they are able to evade immune attack by releasing the TFG-β signaling protein, which blocks NK cell activity. Deleting the TFG-β receptor in NK cells, however, rendered them resistant to this immune suppression and enabled their anti-tumor activity.

Jun 19, 2021

使用 MSCs 干细胞从中风中恢复

Stroke is an abrupt interruption of constant blood flow to the brain that causes loss of neurological function, there are 3 types:  a blocked artery ( ischemic   stroke ) or leaking or bursting of a blood vessel ( hemorrhagic   stroke ) and transient ischemic attack ( TIA also known as a mini stroke ). Different factors can lead to a stroke: high blood pressure, high cholesterol, diabetes, and those who smoke. Mesenchymal Stem Cells (MSCs) are not only safe but also one of the only treatment that can improve the patient condition following a stroke. Study show that with Cerebral artery occlusion model the efficacy of interferon‐γ–activated mesenchymal stem cells (aMSCγ) as an acute therapy for stroke.

Jun 2, 2021

3D打印人体器官更接近真实

研究人员设计了一种新的生物墨水，它首次可以在患者细胞的帮助下对小型人体大小的气道进行 3D 生物打印。 3D 打印的结构具有生物相容性，支持新血管在移植材料中生长。这是迈向 3D 打印器官的重要的第一步。

May 11, 2021

与2型糖尿病相关的肌肉基因

2 型糖尿病患者的肌肉功能往往比其他人差。现在，一个研究小组发现，在 2 型糖尿病中，一个特定的基因对于肌肉干细胞产生新的成熟肌肉细胞的能力非常重要。

May 5, 2021

实验药物显示出对抗阿尔茨海默病的潜力

Researchers have designed an experimental drug that reversed key symptoms of Alzheimer’s disease in mice. The drug works by reinvigorating a cellular cleaning mechanism that gets rid of unwanted proteins by digesting and…

May 5, 2021

实验药物显示出对抗阿尔茨海默病的潜力

Researchers have designed an experimental drug that reversed key symptoms of Alzheimer's disease in mice. The drug works by reinvigorating a cellular cleaning mechanism that gets rid of unwanted proteins by digesting and recycling them.

May 5, 2021

使用各种干细胞的利弊

Abundant somatic cells of donor can be used Issues of histocompatibility with donor/recipient transplants can be avoided Very useful for drug development and developmental studies

May 5, 2021

使用患者自身的干细胞修复受伤的脊髓

Intravenous injection of bone marrow derived stem cells (MSCs) in patients with spinal cord injuries led to significant improvement in motor functions, researchers from Yale University and Japan report Feb. 18 in the Jou…

May 5, 2021

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