{"id":112,"date":"2021-06-24T13:38:00","date_gmt":"2021-06-24T11:38:00","guid":{"rendered":"http:\/\/blog.cell-lavie.com\/?p=112"},"modified":"2022-11-01T05:06:07","modified_gmt":"2022-11-01T05:06:07","slug":"yorkie-drives-ras-induced-tumor-progression-by-microrna-mediated-inhibition-of-cellular-senescence","status":"publish","type":"post","link":"https:\/\/cell-lavie.com\/zh\/yorkie-drives-ras-induced-tumor-progression-by-microrna-mediated-inhibition-of-cellular-senescence\/","title":{"rendered":"Yorkie \u901a\u8fc7 microRNA \u4ecb\u5bfc\u7684\u7ec6\u80de\u8870\u8001\u6291\u5236\u6765\u9a71\u52a8 Ras \u8bf1\u5bfc\u7684\u80bf\u7624\u8fdb\u5c55"},"content":{"rendered":"<p>\u5c3d\u7ba1\u6fc0\u6d3b GTPase Ras \u4e2d\u7684\u7a81\u53d8\u4f1a\u4fc3\u8fdb\u764c\u75c7\uff0c\u4f46 Ras \u4e5f\u4f1a\u8bf1\u5bfc\u7ec6\u80de\u8870\u8001\uff0c\u8fd9\u662f Ras \u6fc0\u6d3b\u4fc3\u8fdb\u80bf\u7624\u8fdb\u5c55\u6240\u5fc5\u9700\u514b\u670d\u7684\u969c\u788d\u3002\u4f7f\u7528 Ras \u8bf1\u5bfc\u7684\u679c\u8747\u80bf\u7624\u751f\u957f\u6a21\u578b\uff0cIto \u548c Igaki \u53d1\u73b0 Ras \u8bf1\u5bfc\u7684\u7ec6\u80de\u8870\u8001\u9700\u8981 ETS \u5bb6\u65cf\u8f6c\u5f55\u56e0\u5b50 Pnt\u3002\u4e0a\u76ae\u8d77\u6e90\u7684\u764c\u75c7\u4e2d\u7ecf\u5e38\u53d1\u751f\u7684\u7ec6\u80de\u6781\u6027\u7f3a\u5931\u6fc0\u6d3b\u8f6c\u5f55\u56e0\u5b50 Yki\uff0c\u5bfc\u81f4\u4e00\u7cfb\u5217 microRNA \u4ecb\u5bfc\u7684\u8c03\u8282\u4e8b\u4ef6\uff0c\u6700\u7ec8\u6291\u5236 Pnt\u3002\u8003\u8651\u5230\u5927\u591a\u6570\u8fd9\u4e9b\u86cb\u767d\u8d28\u7684\u4fdd\u5b88\u6027\u53ca\u5176\u8c03\u8282\u5173\u7cfb\uff0c\u8fd9\u79cd\u673a\u5236\u53ef\u80fd\u4e0e\u7ec6\u80de\u6781\u6027\u7684\u4e27\u5931\u5982\u4f55\u6d88\u9664\u4eba\u7c7b Ras \u8bf1\u5bfc\u7684\u80bf\u7624\u751f\u957f\u7684\u6291\u5236\u6709\u5173\u3002<\/p>\n\n\n<!--more-->\n\n\n<h2 class=\"wp-block-heading\">\u62bd\u8c61\u7684<\/h2>\n\n\n<p id=\"p-4\">\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\uff0cRas \u4fe1\u53f7\u7684\u6fc0\u6d3b\u662f\u80bf\u7624\u53d1\u751f\u7684\u4e3b\u8981\u65e9\u671f\u4e8b\u4ef6\uff0c\u4f46\u77db\u76fe\u7684\u662f\uff0cRas \u4fe1\u53f7\u8bf1\u5bfc\u7ec6\u80de\u8870\u8001\uff0c\u4ece\u800c\u963b\u6b62\u80bf\u7624\u53d1\u751f\u3002\u56e0\u6b64\uff0cRas \u6fc0\u6d3b\u7684\u7ec6\u80de\u5fc5\u987b\u514b\u670d\u8870\u8001\u624d\u80fd\u53d1\u5c55\u6210\u764c\u75c7\u3002\u901a\u8fc7\u57fa\u56e0\u7b5b\u9009\u00a0<em>\u679c\u8747<\/em>, \u6211\u4eec\u53d1\u73b0 ETS \u5bb6\u65cf\u8f6c\u5f55\u6fc0\u6d3b\u56e0\u5b50 Pointed (Pnt) \u662f\u5fc5\u8981\u4e14\u8db3\u4ee5\u5728 Ras \u6fc0\u6d3b\u540e\u89e6\u53d1\u7ec6\u80de\u8870\u8001\uff0c\u5e76\u963b\u6b62 Ras \u8bf1\u5bfc\u7684\u773c\u89e6\u89d2\u76d8\u80bf\u7624\u751f\u957f\u3002\u901a\u8fc7\u4f7f\u7528\u5404\u79cd\u9057\u4f20\u5de5\u5177\u5206\u6790\u9a6c\u8d5b\u514b\u5706\u76d8\uff0c\u6211\u4eec\u786e\u5b9a\u4e86\u4e00\u79cd\u80bf\u7624\u8fdb\u5c55\u673a\u5236\uff0c\u5176\u4e2d\u7ec6\u80de\u6781\u6027\u4e27\u5931\uff08\u4e0a\u76ae\u80bf\u7624\u53d1\u751f\u7684\u5e38\u89c1\u9a71\u52a8\u56e0\u7d20\uff09\u901a\u8fc7 microRNA \u4ecb\u5bfc\u7684 Pnt \u6291\u5236\u6d88\u9664\u4e86 Ras \u8bf1\u5bfc\u7684\u7ec6\u80de\u8870\u8001\u3002\u4ece\u673a\u5236\u4e0a\u8bb2\uff0cRas \u6fc0\u6d3b\u7ec6\u80de\u7684\u6781\u6027\u7f3a\u9677\u5bfc\u81f4 Hippo \u6548\u5e94\u5668 Yorkie (Yki) \u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u8bf1\u5bfc microRNA \u7684\u8868\u8fbe\u00a0<em>\u77ee\u811a\u9e21<\/em>.\u00a0<em>\u77ee\u811a\u9e21<\/em>\u4ecb\u5bfc\u7684 E3 \u8fde\u63a5\u9176\u76f8\u5173\u86cb\u767d Tribbles (Trbl) \u7684\u6291\u5236\u51cf\u8f7b\u4e86\u8f6c\u5f55\u56e0\u5b50 FoxO \u7684 Ras \u548c Akt \u4f9d\u8d56\u6027\u6291\u5236\u3002 Ras \u6fc0\u6d3b\u7ec6\u80de\u4e2d FoxO \u6d3b\u6027\u7684\u6062\u590d\u8bf1\u5bfc\u4e86 microRNA \u7684\u8868\u8fbe\u00a0<em>miR-9c<\/em>\u00a0\u548c\u00a0<em>\u548c\u5e73\u53f7\u7a7a\u95f4\u7ad979<\/em>, \u8fd9\u5bfc\u81f4\u51cf\u5c11\u00a0<em>\u70b9<\/em>\u00a0\u8868\u8fbe\uff0c\u4ece\u800c\u6d88\u9664\u7ec6\u80de\u8870\u8001\u5e76\u4fc3\u8fdb\u80bf\u7624\u8fdb\u5c55\u3002\u6211\u4eec\u7684\u7814\u7a76\u7ed3\u679c\u4e3a Ras \u6fc0\u6d3b\u7684\u80bf\u7624\u5982\u4f55\u901a\u8fc7\u514b\u670d\u7ec6\u80de\u8870\u8001\u800c\u53d1\u5c55\u4e3a\u6076\u6027\u80bf\u7624\u63d0\u4f9b\u4e86\u673a\u5236\u89e3\u91ca\u3002<\/p>\n\n\n<p>\u66f4\u591a\u4fe1\u606f\uff1a <a href=\"https:\/\/stke.sciencemag.org\/content\/14\/685\/eaaz3578.full\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/stke.sciencemag.org\/content\/14\/685\/eaaz3578.full<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Although activating mutations in the GTPase Ras promote cancer, Ras also induces cellular senescence, a barrier that is necessary to overcome for Ras activation to promote tumor progression. Using a model of Ras-induced tumor growth in flies, Ito and Igaki found that Ras-induced cellular senescence required the ETS family transcription factor Pnt. Loss of cell [&hellip;]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[70,71],"tags":[],"featured_image_src":{"landsacpe":false,"list":false,"medium":false,"full":false},"_links":{"self":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts\/112"}],"collection":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/comments?post=112"}],"version-history":[{"count":1,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts\/112\/revisions"}],"predecessor-version":[{"id":633,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts\/112\/revisions\/633"}],"wp:attachment":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/media?parent=112"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/categories?post=112"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/tags?post=112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}