{"id":115,"date":"2021-07-03T15:24:00","date_gmt":"2021-07-03T13:24:00","guid":{"rendered":"http:\/\/blog.cell-lavie.com\/?p=115"},"modified":"2022-11-01T05:06:07","modified_gmt":"2022-11-01T05:06:07","slug":"research-provides-a-roadmap-to-hiv-eradication-via-stem-cell-therapy","status":"publish","type":"post","link":"https:\/\/cell-lavie.com\/zh\/research-provides-a-roadmap-to-hiv-eradication-via-stem-cell-therapy\/","title":{"rendered":"\u7814\u7a76\u63d0\u4f9b\u4e86\u901a\u8fc7\u5e72\u7ec6\u80de\u7597\u6cd5\u6839\u9664 HIV \u7684\u8def\u7ebf\u56fe"},"content":{"rendered":"<p><br \/>\u5728\u4e00\u9879\u5f00\u521b\u6027\u7684\u7814\u7a76\u4e2d\uff0c\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u56e2\u961f\u53d1\u73b0\u4e86\u4e00\u79cd\u7279\u6b8a\u7c7b\u578b\u7684\u5e72\u7ec6\u80de\uff0c\u5b83\u53ef\u4ee5\u51cf\u5c11\u5bfc\u81f4\u827e\u6ecb\u75c5\u7684\u75c5\u6bd2\u6570\u91cf\uff0c\u589e\u5f3a\u4eba\u4f53\u7684\u6297\u75c5\u6bd2\u514d\u75ab\u529b\uff0c\u4fee\u590d\u548c\u6062\u590d\u88ab\u733f\u7334\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\u7834\u574f\u7684\u80a0\u9053\u6dcb\u5df4\u6ee4\u6ce1\uff08 SIV\uff09\uff0c\u76f8\u5f53\u4e8e\u00a0<a href=\"https:\/\/www.cdc.gov\/hiv\/basics\/whatishiv.html\">\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08HIV\uff09<\/a>\u00a0\u5728\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u3002<\/p>\n\n\n<!--more-->\n\n\n<p><a href=\"https:\/\/insight.jci.org\/articles\/view\/149033\">\u7814\u7a76<\/a>, 6 \u6708 22 \u65e5\u53d1\u8868\u4e8e&nbsp;<em>JCI\u6d1e\u5bdf\u529b<\/em>, 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class=\"wp-block-heading\">\u5e72\u7ec6\u80de\u80fd\u5426\u62b5\u6d88 HIV \u9020\u6210\u7684\u80a0\u9053\u635f\u4f24\uff1f<\/h2>\n\n\n<p>\u7814\u7a76\u4eba\u5458\u5728\u827e\u6ecb\u75c5\u6052\u6cb3\u7334\u6a21\u578b\u4e2d\u4f7f\u7528\u9aa8\u9ad3\u6765\u6e90\u7684 MSC\uff0c\u8be5\u6a21\u578b\u56e0\u75c5\u6bd2\u611f\u67d3\u800c\u514d\u75ab\u529b\u53d7\u635f\u5e76\u7834\u574f\u4e86\u80a0\u9053\u529f\u80fd\u3002<\/p>\n\n\n<p>\u201c\u6211\u4eec\u5f00\u59cb\u8ba4\u8bc6\u5230\u8fd9\u4e9b\u5e72\u7ec6\u80de\u5728\u4f20\u67d3\u75c5\u65b9\u9762\u7684\u5de8\u5927\u6f5c\u529b\u3002\u6211\u4eec\u5c1a\u672a\u53d1\u73b0\u8fd9\u4e9b\u5e72\u7ec6\u80de\u5982\u4f55\u5f71\u54cd\u827e\u6ecb\u75c5\u7b49\u6162\u6027\u75c5\u6bd2\u611f\u67d3\uff0c\u201dDandekar \u8bf4\u3002\u5979\u662f\u6559\u6388\u548c\u4e3b\u5e2d&nbsp;<a href=\"https:\/\/health.ucdavis.edu\/medmicro\/\">\u533b\u5b66\u5fae\u751f\u7269\u5b66\u548c\u514d\u75ab\u5b66\u7cfb<\/a>&nbsp;\u5728\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821\u5e76\u9644\u5c5e\u4e8e&nbsp;<a href=\"https:\/\/cnprc.ucdavis.edu\/\">\u52a0\u5dde\u56fd\u5bb6\u7075\u957f\u7c7b\u52a8\u7269\u7814\u7a76\u4e2d\u5fc3\u3002<\/a><\/p>\n\n\n<p>\u7814\u7a76\u53d1\u73b0\uff0cMSCs \u53ef\u4ee5\u8c03\u8282\u3001\u6539\u53d8\u548c\u91cd\u5851\u53d7\u635f\u7684\u7c98\u819c\u90e8\u4f4d\u3002\u7acb\u7aff\u89c1\u5f71\u7684\u597d\u5904\u662f\uff0c\u9488\u5bf9\u8be5\u75c5\u6bd2\u7684\u6297\u4f53\u548c T \u514d\u75ab\u7ec6\u80de\u8fc5\u901f\u589e\u52a0\u3002\u5e72\u7ec6\u80de\u6709\u52a9\u4e8e\u6062\u590d\u548c\u4fee\u590d\u8fd9\u4e9b\u6dcb\u5df4\u6ee4\u6ce1\u3002<\/p>\n\n\n<p>MSCs \u8fd8\u901a\u8fc7\u8865\u5145\u5f53\u524d\u7684 HIV \u6cbb\u7597\uff0c\u4e3a\u521b\u65b0\u7684\u3001\u591a\u7ba1\u9f50\u4e0b\u7684 HIV \u6cbb\u7597\u7b56\u7565\u63d0\u4f9b\u4e86\u673a\u4f1a\u3002<\/p>\n\n\n<p>\u201c\u5e72\u7ec6\u80de\u662f\u4e0e\u836f\u7269\u5f88\u597d\u7684\u534f\u540c\u6210\u5206\u3002\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\u53ef\u4ee5\u963b\u6b62\u75c5\u6bd2\u611f\u67d3\u4e4b\u706b\uff0c\u4f46\u4e0d\u80fd\u6062\u590d\u6dcb\u5df4\u7ec4\u7ec7\u9694\u5ba4\u7684\u68ee\u6797\u3002 MSC \u5c06\u4f7f\u8be5\u9886\u57df\u6062\u590d\u6d3b\u529b\u5e76\u6062\u590d\u514d\u75ab\u6d3b\u529b\uff0c\u201dDandekar \u8bf4\u3002<\/p>\n\n\n<p>\u5373\u4f7f\u4e0d\u4f7f\u7528\u6297\u75c5\u6bd2\u836f\u7269\uff0cMSCs \u4e5f\u80fd\u591f\u901a\u8fc7\u4fee\u590d\u6dcb\u5df4\u6ee4\u6ce1\u3001\u6062\u590d\u7c98\u819c\u514d\u75ab\u529b\u548c\u6062\u590d\u75c5\u6bd2\u65e9\u671f\u653b\u51fb\u7684\u76ee\u6807\u6765\u589e\u5f3a\u5bbf\u4e3b\u7684\u6297\u75c5\u6bd2\u53cd\u5e94\u3002<\/p>\n\n\n<h2 class=\"wp-block-heading\">MSC\u6cbb\u7597<\/h2>\n\n\n<p>MSC \u6cbb\u7597\u9700\u8981\u660e\u786e\u5b9a\u4e49\u7684\u7ec6\u80de\u8d28\u91cf\u63a7\u5236\u548c\u7279\u5b9a\u7684\u4f20\u9012\u673a\u5236\u3002\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821&nbsp;<a href=\"https:\/\/health.ucdavis.edu\/stemcellresearch\/\">\u5e72\u7ec6\u80de<\/a>Program \u662f\u4e00\u4e2a\u5353\u8d8a\u7684\u5e72\u7ec6\u80de\u7814\u7a76\u4e2d\u5fc3\uff0c\u6b63\u5728\u9886\u5bfc\u591a\u4e2a&nbsp;<a href=\"https:\/\/health.ucdavis.edu\/stemcellresearch\/cores\/msc_core.html\">MSC\u7528\u4e8e\u6cbb\u7597\u75be\u75c5\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/a>&nbsp;\u5982\u810a\u67f1\u88c2\u548c\u4ea8\u5ef7\u987f\u821e\u8e48\u75c5\u3002\u672c\u7814\u7a76\u7684\u7ed3\u679c\u4e3a\u7814\u7a76 MSC \u5728\u4e34\u5e8a\u73af\u5883\u4e2d\u6cbb\u7597 HIV \u548c\u5176\u4ed6\u4f20\u67d3\u75c5\u63d0\u4f9b\u4e86\u79d1\u5b66\u4f9d\u636e\u3002<\/p>\n\n\n<p>###<\/p>\n\n\n<p>\u8fd9\u9879\u7814\u7a76\u7684\u5171\u540c\u4f5c\u8005\u662f Mariana G. Weber\u3001Chara J. Walters-Laird\u3001Clarissa Santos Rocha\u3001Lauren A. Hirao\u3001Abigail Mende\u3001Juan Arredondo\u3001Amir Kol\u3001Sonny R. Elizaldi\u3001Smita S. Iyer \u548c Alice Tarantal\u52a0\u5dde\u5927\u5b66\u6234\u7ef4\u65af\u5206\u6821\u548c\u610f\u5927\u5229\u5df4\u52d2\u83ab\u5927\u5b66\u7684 Bipin Balan\u3002<\/p>\n\n\n<p>\u8fd9\u9879\u5de5\u4f5c\u5f97\u5230\u4e86\u56fd\u5bb6\u536b\u751f\u7814\u7a76\u9662 (R01AI 153025\u3001R21 AI 116415\u3001R21AI34368 \u548c OD P51 OD011107) \u548c\u5df4\u897f\u56fd\u5bb6\u79d1\u5b66\u6280\u672f\u53d1\u5c55\u59d4\u5458\u4f1a (CNPq) \u7684\u652f\u6301\u3002<\/p>\n\n\n<p>\u6587\u7ae0\uff1a\u97e6\u4f2f\u7b49\u4eba\u3002 (2021) \u95f4\u5145\u8d28\u5e72\u7ec6\u80de\/\u57fa\u8d28\u7ec6\u80de\u5728 SIV \u611f\u67d3\u4e2d\u7684\u80a0\u9053\u751f\u53d1\u4e2d\u5fc3\u518d\u751f\u548c\u6297\u75c5\u6bd2\u514d\u75ab\u589e\u5f3a\u3002&nbsp;<em>JCI\u6d1e\u5bdf\u529b<\/em>. 6(12)\uff0c\u571f\u4e95\uff1a<a href=\"https:\/\/insight.jci.org\/articles\/view\/149033\" rel=\"noreferrer noopener\" target=\"_blank\">10.1172\/jci\u3002\u6d1e\u5bdf\u529b.149033<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>In a groundbreaking study, a team of UC Davis researchers has discovered a special type of stem cell that can reduce the amount of the virus causing AIDS, boosting the body\u2019s antiviral immunity and repairing and restoring the gut\u2019s lymphoid follicles damaged by the simian immunodeficiency virus (SIV), the equivalent of the\u00a0human immunodeficiency virus (HIV)\u00a0in [&hellip;]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[70,83,71],"tags":[],"class_list":["post-115","post","type-post","status-publish","format-standard","hentry","category-blog","category-mscs","category-stem-cells"],"featured_image_src":{"landsacpe":false,"list":false,"medium":false,"full":false},"_links":{"self":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts\/115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/comments?post=115"}],"version-history":[{"count":1,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts\/115\/revisions"}],"predecessor-version":[{"id":632,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts\/115\/revisions\/632"}],"wp:attachment":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/media?parent=115"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/categories?post=115"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/tags?post=115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}