{"id":84,"date":"2021-05-05T14:53:14","date_gmt":"2021-05-05T12:53:14","guid":{"rendered":"http:\/\/blog.cell-lavie.com\/?p=84"},"modified":"2022-11-01T05:06:54","modified_gmt":"2022-11-01T05:06:54","slug":"mscs-stem-cells-with-severe-covid-19-ards","status":"publish","type":"post","link":"https:\/\/cell-lavie.com\/zh\/mscs-stem-cells-with-severe-covid-19-ards\/","title":{"rendered":"\u60a3\u6709\u4e25\u91cd COVID-19 ARDS \u7684 MSC \u5e72\u7ec6\u80de"},"content":{"rendered":"<p>\u76ee\u524d\u8feb\u5207\u9700\u8981\u6539\u8fdb COVID-19 \u80ba\u708e\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u7279\u522b\u662f\u5728\u53d7\u5f71\u54cd\u6700\u4e25\u91cd\u7684\u60a3\u8005\u4e2d\u3002\u6210\u4eba\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (MSC) \u8f93\u6ce8\u6709\u53ef\u80fd\u4f7f\u611f\u67d3\u6025\u6027\u547c\u5438\u7cfb\u7edf\u7efc\u5408\u75c7 SARS-COV-2 \u7684\u5371\u91cd\u60a3\u8005\u53d7\u76ca\uff0c\u4f46\u7f3a\u4e4f\u652f\u6301\u7597\u6548\u7684\u4e34\u5e8a\u6570\u636e\u3002<\/p>\n\n\n<!--more-->\n\n\n<p id=\"p-3\"><strong>\u65b9\u6cd5<\/strong>&nbsp;\u6211\u4eec\u5bf9\u5b9e\u9a8c\u5ba4\u786e\u8bca\u7684 COVID-19\u3001\u4e25\u91cd\u6025\u6027\u547c\u5438\u7a98\u8feb\u7efc\u5408\u5f81 (ARDS) \u91cd\u75c7\u60a3\u8005\u8fdb\u884c\u4e86\u75c5\u4f8b\u5bf9\u7167\u7814\u7a76\u3002\u4e3a\u4e86\u8bc4\u4f30\u6700\u5371\u91cd\u60a3\u8005\u7684\u4e34\u5e8a\u53cd\u5e94\uff0c\u6211\u4eec\u68c0\u67e5\u4e86\u9700\u8981\u4f53\u5916\u819c\u6c27\u5408 (ECMO) \u652f\u6301\u7684\u4e9a\u7ec4\u60a3\u8005\u7684\u7ed3\u679c\u3002\u60a3\u8005 (n=9) \u6700\u591a\u63a5\u53d7 3 \u6b21\u9759\u8109\u5185 (IV) MSCs \u8f93\u6ce8\uff0c\u5e76\u4e0e\u5c40\u90e8 ECMO \u5bf9\u7167\u7ec4 (n=31) \u8fdb\u884c\u6bd4\u8f83\u3002\u4e3b\u8981\u7ed3\u679c\u662f\u5b89\u5168\u6027\uff0c\u6b21\u8981\u7ed3\u679c\u662f\u5168\u56e0\u6b7b\u4ea1\u7387\uff08\u6216\u51fa\u9662\u7387\uff09\u3001\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u548c\u75c5\u6bd2\u6e05\u9664\u7387\u3002<\/p>\n\n\n<p id=\"p-4\"><strong>\u53d1\u73b0<\/strong>&nbsp;MSC \u8f93\u6ce8\uff0812 \u540d\u60a3\u8005\uff09\u8010\u53d7\u6027\u826f\u597d\uff0c\u6ca1\u6709\u53d1\u751f\u526f\u4f5c\u7528\u3002\u5728\u63a5\u53d7 MSC \u8f93\u6ce8\u7684 ECMO \u60a3\u8005\u4e2d\uff0c9 \u4eba\u4e2d\u6709 2 \u4eba\u6b7b\u4ea1\uff0822.2%\uff1b95%CI\uff1a2.8%\uff0c60.0%\uff09\uff0c\u800c 31 \u4eba\u4e2d\u6709 15 \u4eba\u6b7b\u4ea1\uff0848.4%\uff1b95%CI\uff1a30.2%\uff0c66.9%\uff1bp = 0.25\uff09 ECMO\u5bf9\u7167\u7ec4\u3002\u5728\u7ed9\u836f\u540e\u7b2c 14 \u5929\u6216\u7b2c 21 \u5929\uff0cMSC \u8f93\u6ce8\u540e\uff0c\u542b\u6709 SARS-COV-2 \u523a\u7a81\u86cb\u767d\u7684\u5206\u79bb\u8840\u6d46\u5916\u6ccc\u4f53\u51cf\u5c11\uff08\u5206\u522b\u4e3a p=0.003 \u548c p=0.005\uff09\uff0c\u540c\u65f6\u4e0e COVID-19 IgG \u523a\u7a81\u86cb\u767d\u6ef4\u5ea6\u964d\u4f4e\u76f8\u5173\u65f6\u95f4\u70b9\uff08\u5206\u522b\u4e3a p = 0.006 \u548c p = 0.007\uff09\u3002\u63a5\u53d7\u6062\u590d\u671f\u8840\u6d46\u7684\u5bf9\u7167 ECMO \u60a3\u8005\u5728\u540c\u4e00\u65f6\u95f4\u6bb5\u5185\u672a\u6e05\u9664 COVID-19 IgG\u3002<\/p>\n\n\n<p id=\"p-5\"><strong>\u89e3\u91ca<\/strong>&nbsp;\u8fd9\u4e9b\u53d1\u73b0\u5171\u540c\u8868\u660e\uff0cMSC IV \u8f93\u6ce8\u5728\u4e25\u91cd\u7a0b\u5ea6\u8303\u56f4\u5e7f\u6cdb\u7684\u60a3\u8005\u4e2d\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5305\u62ec\u9700\u8981 ECMO \u7684\u6700\u4e25\u91cd\u7684 COVID-19 ARDS\u3002\u8fd9\u4e9b\u6570\u636e\u8fd8\u63d0\u51fa\u4e86\u4e00\u79cd\u53ef\u80fd\u6027\uff0c\u5373 MSCs \u9664\u4e86\u53d1\u6325\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u5916\uff0c\u8fd8\u6709\u52a9\u4e8e\u75c5\u6bd2\u6e05\u9664\uff0c\u5e76\u5f3a\u70c8\u652f\u6301\u8fdb\u884c\u968f\u673a\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u7ade\u4e89\u5229\u76ca\u58f0\u660e<\/h3>\n\n\n<p id=\"p-6\">\u5229\u76ca\u51b2\u7a81\u62ab\u9732\uff1aJoshua Hare \u535a\u58eb\u62a5\u544a\u8bf4\u4ed6\u62e5\u6709\u57fa\u4e8e\u5fc3\u810f\u7ec6\u80de\u7684\u7597\u6cd5\u7684\u4e13\u5229\u3002\u4ed6\u6301\u6709 Vestion Inc. \u7684\u80a1\u6743\uff0c\u5e76\u4f5c\u4e3a\u987e\u95ee\u4ee5\u53ca\u8463\u4e8b\u4f1a\u548c\u79d1\u5b66\u987e\u95ee\u59d4\u5458\u4f1a\u6210\u5458\u4e0e Vestion Inc. \u4fdd\u6301\u4e13\u4e1a\u5173\u7cfb\u3002 Hare \u535a\u58eb\u662f Longeveron \u7684\u9996\u5e2d\u79d1\u5b66\u5b98\u3001\u6709\u507f\u987e\u95ee\u548c\u987e\u95ee\u59d4\u5458\u4f1a\u6210\u5458\uff0c\u5e76\u6301\u6709 Longeveron \u7684\u80a1\u6743\u3002 Hare \u535a\u58eb\u8fd8\u662f\u6388\u6743\u7ed9 Longeveron \u7684\u77e5\u8bc6\u4ea7\u6743\u7684\u5171\u540c\u53d1\u660e\u4eba\u3002 A. Khan \u62ab\u9732\u4e86\u4e0e AssureImmune Cord Blood Bank \u548c Aceso Therapeutic \u7684\u5173\u7cfb\uff0c\u5176\u4e2d\u5305\u62ec\u80a1\u6743\u3002 Sunjay Kaushal \u535a\u58eb\u662f Neoprogen \u7684\u521b\u59cb\u4eba\u3002\u5176\u4ed6\u4f5c\u8005\u62a5\u544a\u6ca1\u6709\u51b2\u7a81\u3002&nbsp;<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u4e34\u5e8a\u8bd5\u9a8c<\/h3>\n\n\n<p id=\"p-7\">\u8bd5\u9a8c\u662f\u6839\u636e FDA \u7d27\u6025 IND (eIND) \u2013 21CFR 312 \u8fdb\u884c\u7684<\/p>\n\n\n<p><strong>doi:<\/strong>\u00a0<a href=\"https:\/\/doi.org\/10.1101\/2020.10.15.20122523\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1101\/2020.10.15.20122523<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u76ee\u524d\u8feb\u5207\u9700\u8981\u6539\u8fdb COVID-19 \u80ba\u708e\u7684\u6cbb\u7597\u7b56\u7565\uff0c\u7279\u522b\u662f\u5728\u53d7\u5f71\u54cd\u6700\u4e25\u91cd\u7684\u60a3\u8005\u4e2d\u3002\u6210\u4eba\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (MSC) \u8f93\u6ce8\u6709\u53ef\u80fd\u4f7f\u611f\u67d3\u6025\u6027\u547c\u5438\u7cfb\u7edf\u7efc\u5408\u75c7 SARS-COV-2 \u7684\u5371\u91cd\u60a3\u8005\u53d7\u76ca\uff0c\u4f46\u7f3a\u4e4f\u652f\u6301\u7597\u6548\u7684\u4e34\u5e8a\u6570\u636e\u3002<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[70,72,83,71],"tags":[84,81],"class_list":["post-84","post","type-post","status-publish","format-standard","hentry","category-blog","category-covid-19","category-mscs","category-stem-cells","tag-mscs","tag-stem-cells"],"featured_image_src":{"landsacpe":false,"list":false,"medium":false,"full":false},"_links":{"self":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts\/84","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/comments?post=84"}],"version-history":[{"count":1,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts\/84\/revisions"}],"predecessor-version":[{"id":644,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/posts\/84\/revisions\/644"}],"wp:attachment":[{"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/media?parent=84"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/categories?post=84"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cell-lavie.com\/zh\/wp-json\/wp\/v2\/tags?post=84"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}