{"id":98,"date":"2021-06-02T18:03:34","date_gmt":"2021-06-02T16:03:34","guid":{"rendered":"http:\/\/blog.cell-lavie.com\/?p=98"},"modified":"2022-11-01T05:06:53","modified_gmt":"2022-11-01T05:06:53","slug":"recovering-from-a-stroke-with-mscs-stem-cells","status":"publish","type":"post","link":"https:\/\/cell-lavie.com\/zh\/recovering-from-a-stroke-with-mscs-stem-cells\/","title":{"rendered":"\u4f7f\u7528 MSCs \u5e72\u7ec6\u80de\u4ece\u4e2d\u98ce\u4e2d\u6062\u590d"},"content":{"rendered":"<p>\u4e2d\u98ce\u662f\u6d41\u5411\u5927\u8111\u7684\u6301\u7eed\u8840\u6db2\u7a81\u7136\u4e2d\u65ad\uff0c\u5bfc\u81f4\u795e\u7ecf\u529f\u80fd\u4e27\u5931\uff0c\u6709 3 \u79cd\u7c7b\u578b\uff1a\u52a8\u8109\u963b\u585e\uff08<strong>\u7f3a\u8840\u7684<\/strong>\u00a0<strong>\u4e2d\u98ce<\/strong>) \u6216\u8840\u7ba1\u6e17\u6f0f\u6216\u7834\u88c2 (<strong>\u51fa\u8840\u6027\u7684<\/strong>\u00a0<strong>\u4e2d\u98ce<\/strong>) \u548c\u77ed\u6682\u6027\u8111\u7f3a\u8840\u53d1\u4f5c (<strong>TIA<\/strong> \u4e5f\u79f0\u4e3a\u8ff7\u4f60\u4e2d\u98ce\uff09\u3002\u4e0d\u540c\u7684\u56e0\u7d20\u53ef\u5bfc\u81f4\u4e2d\u98ce\uff1a\u9ad8\u8840\u538b\u3001\u9ad8\u80c6\u56fa\u9187\u3001\u7cd6\u5c3f\u75c5\u548c\u5438\u70df\u8005\u3002\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (MSC) \u4e0d\u4ec5\u5b89\u5168\uff0c\u800c\u4e14\u662f\u552f\u4e00\u53ef\u4ee5\u6539\u5584\u4e2d\u98ce\u540e\u60a3\u8005\u72b6\u51b5\u7684\u6cbb\u7597\u65b9\u6cd5\u4e4b\u4e00\u3002\u7814\u7a76\u8868\u660e\uff0c\u5728\u8111\u52a8\u8109\u95ed\u585e\u6a21\u578b\u4e2d\uff0c\u5e72\u6270\u7d20-\u03b3-\u6fc0\u6d3b\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (aMSC\u03b3) \u4f5c\u4e3a\u4e2d\u98ce\u6025\u6027\u6cbb\u7597\u7684\u529f\u6548\u3002<\/p>\n\n\n<!--more-->\n\n\n<p>\u51fa\u8840\u6027\u4e2d\u98ce\u5360\u6240\u6709\u4e2d\u98ce\u7684 13%\uff0c\u4f46\u5360\u4e2d\u98ce\u76f8\u5173\u6b7b\u4ea1\u7684 40%\uff0c\u800c\u7f3a\u8840\u6027\u4e2d\u98ce\u5360 87%\u3002\u6b64\u5916\uff0c\u591a\u8fbe 50% \u7684\u4e2d\u98ce\u60a3\u8005\u5728\u521d\u6b21\u53d1\u4f5c\u540e 1 \u5e74\u4ecd\u4f9d\u8d56\u62a4\u7406\uff0c\u5e76\u62a5\u544a\u8bb0\u5fc6\u3001\u8bed\u8a00\u548c\u65e5\u5e38\u6d3b\u52a8\u53d7\u635f\u3002\u51fa\u8840\u6027\u4e2d\u98ce\u662f\u7531\u8840\u7ba1\u7834\u88c2\u548c\u968f\u540e\u8840\u6db2\u5916\u6e17\u5230\u9885\u5185\u5f15\u8d77\u7684\uff0c\u6839\u636e\u51fa\u8840\u90e8\u4f4d\u53ef\u8fdb\u4e00\u6b65\u5206\u4e3a\u86db\u7f51\u819c\u4e0b\u8154\u51fa\u8840\uff08SAH\uff09\u3001\u8111\u51fa\u8840\uff08ICH\uff09\u548c\u8111\u5ba4\u5185\u51fa\u8840\uff08IVH\uff09\u7b49\u4e9a\u578b\u3002 ).\u8111\u51fa\u8840\u4f1a\u5bfc\u81f4\u5468\u56f4\u7ec4\u7ec7\u7f3a\u6c27\u548c\u8461\u8404\u7cd6\uff0c\u5e76\u5f15\u53d1\u7ee7\u53d1\u6027\u708e\u75c7\u53cd\u5e94\uff0c\u4ece\u800c\u5bfc\u81f4\u75c5\u53d8\u6269\u5927\uff0c\u5bf9\u60a3\u8005\u7684\u9884\u540e\u6709\u5bb3\uff0c\u5e76\u4e14\u7f3a\u4e4f\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n\n\n<figure class=\"wp-block-video\"><video controls src=\"http:\/\/blog.cell-lavie.com\/wp-content\/uploads\/2021\/06\/MSCs_clv_w3.mp4\"><\/video><figcaption>\u4ec0\u4e48\u662f MSC\uff1f<\/figcaption><\/figure>\n\n\n<p>\u7814\u7a76\u4f7f\u7528\u4eba\u7c7b\u6765\u6e90\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u9885\u5185\u51fa\u8840\u3002\u5927\u7ea6 60% \u7684 MSCs \u6765\u81ea\u9aa8\u9ad3 (BM-MSCs)\uff0c\u56e0\u4e3a\u8fd9\u662f\u6765\u81ea\u4e24\u4e2a\u4eba\u7c7b\u7684\u53ef\u884c\u6765\u6e90\uff0c\u800c\u8110\u5e26\/\u80ce\u76d8\/\u7f8a\u819c\u6765\u6e90\u7684\u7ec6\u80de\u7528\u4e8e\u5927\u7ea6\u56db\u5206\u4e4b\u4e00\u7684\u7814\u7a76\uff0c\u5176\u4f59\u6765\u81ea\u8102\u80aa\u7ec4\u7ec7 (AT-MSC)\u3002\u540e\u4e00\u79cd\u6765\u6e90\u5747\u6765\u81ea\u4eba\u4f53\u7ec4\u7ec7\u3002 MSCs \u7684\u4e00\u822c\u7279\u5f81\u662f\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u672f\u6216\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u65b9\u6cd5\u8bc4\u4f30\u7684\u7ec6\u80de\u8868\u9762\u6807\u5fd7\u7269\u7684\u8868\u8fbe\u3002 MSC \u5bf9 CD29\u3001CD44\u3001CD73\u3001CD90 \u548c CD105 \u7b49\u5448\u9633\u6027\uff0c\u5bf9\u9020\u8840\u8c31\u7cfb\u6807\u5fd7\u7269 CD14\u3001CD34 \u548c CD45\u3001\u5e72\u7ec6\u80de\u6807\u5fd7\u7269 CD133 \u548c\u5185\u76ae\u7ec6\u80de\u6807\u5fd7\u7269 CD144 \u5448\u9634\u6027\uff0c<sup><a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR30\">30<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR31\">31<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR32\">32<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR33\">33<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR34\">34<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR35\">35<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR36\">36<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR37\">37<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR38\">38<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR39\">39<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR40\">40<\/a>,<a href=\"https:\/\/www.nature.com\/articles\/s41536-019-0073-8#ref-CR41\">41<\/a><\/sup>\u00a0\u8fd9\u4e0e\u51c6\u5219\u4e00\u81f4\u3002<\/p>\n\n\n<figure class=\"wp-block-image size-large is-resized is-style-default\"><img decoding=\"async\" src=\"http:\/\/blog.cell-lavie.com\/wp-content\/uploads\/2021\/06\/mscs-933x1024.jpg\" alt=\"\" class=\"wp-image-99\" width=\"840\" height=\"921\" title=\"\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6765\u6e90\"\/><\/figure>\n\n\n<p><\/p>\n\n\n<h3 class=\"wp-block-heading\">\u8110\u5e26\u8840\u5e72\u7ec6\u80de<\/h3>\n\n\n<p>\u4eba\u8110\u5e26\u8840\u5e72\u7ec6\u80de (UC-BSC) \u6765\u6e90\u4e8e\u51fa\u751f\u540e\u7684\u80ce\u76d8\u7ec4\u7ec7\u3002\u5b83\u4eec\u7531\u9020\u8840\u5e72\u7ec6\u80de\u548c\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7ec4\u6210\u3002\u8fd9\u4e9b\u7ec6\u80de\u5177\u6709\u8bb8\u591a\u5173\u952e\u4f18\u52bf\uff0c\u4f8b\u5982\u7ec6\u80de\u6765\u6e90\u5145\u8db3\u3001\u4f9b\u4f53\u5e74\u9f84\u4f4e\uff0c\u4ee5\u53ca\u5728\u91c7\u96c6\u8fc7\u7a0b\u4e2d\u5bf9\u5a74\u513f\u548c\u6bcd\u4eb2\u7684\u98ce\u9669\u4f4e\uff0c\u4ece\u800c\u6700\u5927\u9650\u5ea6\u5730\u51cf\u5c11\u4e86\u4f26\u7406\u95ee\u9898\u3002\u8fd9\u4e9b\u7ec6\u80de\u53ef\u4ee5\u5206\u5316\u6210\u795e\u7ecf\u7956\u7ec6\u80de\uff0c\u5e76\u901a\u8fc7\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u5206\u6ccc\u548c\u8111\u5352\u4e2d\u540e\u8840\u7ba1\u91cd\u5851\u589e\u5f3a\u5728\u8111\u7f3a\u8840\u4e2d\u63d0\u4f9b\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528\u3002<a rel=\"noreferrer noopener\" href=\"https:\/\/www.longdom.org\/open-access\/application-umbilical-cord-blood-derived-stem-cells-diseases-nervous-system-2157-7633.1000202.pdf\" data-type=\"URL\" target=\"_blank\">62<\/a>,<a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26279113\/\" data-type=\"URL\" target=\"_blank\">63<\/a>]. UC-BSCs\u5bf9\u7f3a\u8840\u6027\u635f\u4f24\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\uff0c\u5bfc\u81f4\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u8868\u8fbe\u6062\u590d[<a rel=\"noreferrer noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4711929\/\" target=\"_blank\">64<\/a>].\u6b64\u5916\uff0cUC-BSCs \u53ef\u4ee5\u6291\u5236\u514d\u75ab\u53cd\u5e94\u5e76\u51cf\u5c0f\u7f3a\u8840\u6027\u8111\u635f\u4f24\u7684\u5927\u5c0f [<a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31066288\/\" target=\"_blank\">65<\/a>].\u00a0<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u5e72\u7ec6\u80de\u7ed9\u836f\u9014\u5f84<\/h3>\n\n\n<h4 class=\"wp-block-heading\">\u9759\u8109\u7ed9\u836f<\/h4>\n\n\n<p>IV \u7ed9\u836f\u907f\u514d\u4e86\u76f4\u63a5\u8fdb\u5165 CNS \u7684\u9700\u8981\uff0c\u4ece\u800c\u51cf\u5c11\u4e86\u4fb5\u5165\u6027 [<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b60-jos-2019-03048\">60<\/a>,<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b68-jos-2019-03048\">68<\/a>].\u9759\u8109\u6ce8\u5c04\u7684 NSCs \u53ef\u4ee5\u7a7f\u8fc7 BBB \u5e76\u5b9a\u4f4d\u5230\u7f3a\u8840\u6027\u635f\u4f24\u533a\u57df\u3002 NSCs\u3001BM-MSCs\u3001AD-MSCs \u6216 UC-BSCs IV \u7ed9\u836f\u5df2\u663e\u793a\u5728\u7f3a\u8840\u6027\u4e2d\u98ce\u4e2d\u7684\u795e\u7ecf\u4fdd\u62a4\u4f5c\u7528 [<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b39-jos-2019-03048\">39<\/a>,<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b48-jos-2019-03048\">48<\/a>,<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b60-jos-2019-03048\">60<\/a>,<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b64-jos-2019-03048\">64<\/a>,<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b65-jos-2019-03048\">65<\/a>,<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b69-jos-2019-03048\">69<\/a>].<\/p>\n\n\n<p><\/p>\n\n\n<h4 class=\"wp-block-heading\">\u52a8\u8109\u5185\u5206\u5a29<\/h4>\n\n\n<p>\u52a8\u8109\u5185 (IA) \u9012\u9001\u4f7f\u7528\u5bfc\u7ba1\u63d2\u5165\u672f\u5c06\u5e72\u7ec6\u80de\u5f15\u5bfc\u81f3\u9888\u52a8\u8109\u6216 Willis \u73af\uff0c\u4ece\u800c\u7ed5\u8fc7\u5168\u8eab\u5668\u5b98\u7684\u521d\u59cb\u6444\u53d6\u3002 IA \u7ed9\u836f\u5df2\u88ab\u8bc1\u660e\u6709\u5229\u4e8e\u635f\u4f24\u90e8\u4f4d\u7684 MSC \u9012\u9001 [<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b78-jos-2019-03048\">78<\/a>&#8211;<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b80-jos-2019-03048\">80<\/a>].\u8fd9\u79cd\u9012\u9001\u65b9\u6cd5\u5141\u8bb8\u7ed5\u8fc7\u80ba\u90e8\u5e76\u907f\u514d\u80ba\u90e8\u6ede\u7559 [<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b72-jos-2019-03048\">72<\/a>].\u867d\u7136\u8fd9\u79cd\u65b9\u6cd5\u5c06\u5927\u91cf\u7ec6\u80de\u8f93\u9001\u5230\u8111\u75c5\u7076\uff0c\u4f46\u5b83\u4e5f\u5b58\u5728\u5fae\u6813\u585e\u548c\u8111\u7f3a\u8840\u7684\u98ce\u9669\uff0c\u56e0\u4e3a\u52a8\u8109\u7ec6\u80de\u805a\u96c6\u548c\u7ed3\u5757\uff0c\u5bfc\u81f4\u8111\u8840\u6d41\u51cf\u5c11[<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b81-jos-2019-03048\">81<\/a>&#8211;<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b83-jos-2019-03048\">83<\/a>].\u8111\u5ba4\u5185\u5206\u5a29<\/p>\n\n\n<h4 class=\"wp-block-heading\">\u5ba4\u5185\u5206\u5a29<\/h4>\n\n\n<p>\u8111\u5ba4\u5185\u9012\u9001\u5141\u8bb8\u76f4\u63a5\u9012\u9001\u5230\u8111\u810a\u9ad3\u6db2\uff08CSF\uff09\u6216\u95f4\u8d28\u7ec4\u7ec7\u4e2d\uff0c\u4ece\u800c\u5141\u8bb8\u901a\u8fc7CSF\u5206\u6563\u5230\u5927\u8111\u548cCNS\u7684\u591a\u4e2a\u90e8\u4f4d\u3002\u5c3d\u7ba1\u8fd9\u79cd\u6280\u672f\u5177\u6709\u4fb5\u5165\u6027\uff0c\u4f46\u901a\u8fc7\u9002\u5f53\u7684\u8bad\u7ec3\u548c\u6280\u672f\u53ef\u4ee5\u51cf\u5c11\u5e76\u53d1\u75c7<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u8179\u819c\u5185<\/h3>\n\n\n<p>\u4eba\u95f4\u5145\u8d28\u5e72\u7ec6\u80de (hMSCs) \u7684\u8179\u819c\u5185 (IP) \u7ed9\u836f\u5bfc\u81f4\u8179\u8154\u5185\u7ec6\u80de\u5feb\u901f\u805a\u96c6\uff0c\u53ea\u6709\u5c11\u91cf\u7ec6\u80de\u8fc1\u79fb\u5230\u5176\u4ed6\u5730\u65b9 [<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b89-jos-2019-03048\">89<\/a>].\u4e0e hMSC IV \u6ce8\u5c04\u76f8\u6bd4\uff0cIP \u7ed9\u836f\u5bfc\u81f4\u5916\u5468\u7ec4\u7ec7\uff08\u5982\u80ba\u548c\u809d\u810f\uff09\u7684\u84c4\u79ef\u51cf\u5c11\u3002\u7136\u800c\uff0cIP \u9012\u9001\u7684\u8110\u5e26\u6765\u6e90\u7684\u95f4\u5145\u8d28\u57fa\u8d28\u7ec6\u80de (UC-MSC) \u5bf9\u7f3a\u8840\u6027\u989d\u53f6\u76ae\u5c42\u7684\u5b9a\u4f4d\u8f83\u5dee [<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b90-jos-2019-03048\">90<\/a>]\uff0c\u8868\u660e\u5927\u8111\u6e17\u900f\u6709\u9650\u3002<\/p>\n\n\n<h3 class=\"wp-block-heading\">\u5b9e\u8d28\u5185<\/h3>\n\n\n<p>\u5c40\u90e8\u8111\u5b9e\u8d28\u5185\u9012\u9001\u5141\u8bb8\u66f4\u9ad8\u7684\u7ec6\u80de\u4f53\u79ef\u5230\u8fbe\u8111\u90e8\u9776\u75c5\u7076[<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b91-jos-2019-03048\">91<\/a>]\uff0c\u4ece\u800c\u9632\u6b62\u8131\u9776\u6548\u5e94\u5e76\u63d0\u9ad8\u6210\u672c\u6548\u76ca\u3002\u4eba\u7c7b AD-MSCs \u7684\u9885\u5185\u79fb\u690d\u88ab\u8bc1\u660e\u53ef\u4ee5\u4fc3\u8fdb\u8111\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u4e2d\u7684\u795e\u7ecf\u5143\u4fee\u590d [<a href=\"https:\/\/www.j-stroke.org\/journal\/view.php?number=333#b54-jos-2019-03048\">54<\/a>]. 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