Although activating mutations in the GTPase Ras promote cancer, Ras also induces cellular senescence, a barrier that is necessary to overcome for Ras activation to promote tumor progression. Using a model of Ras-induced tumor growth in flies, Ito and Igaki found that Ras-induced cellular senescence required the ETS family transcription...
Scientists at UC Santa Barbara, University of Southern California (USC), and the biotechnology company Regenerative Patch Technologies LLC (RPT) have reported new methodology for preservation of RPT's stem cell-based therapy for age-related macular degeneration (AMD). (more…)
The spinal cord is an important component of our central nervous system: it connects the brain with the rest of the body and plays a crucial part in coordinating our sensations with our actions. Falls, violence, disease—various forms of trauma can cause irreversible damage to the spinal cord, leading to...
Deleting the TFG-β receptor in NK cells overcame immune suppression and enabled anti-tumor activity in preclinical models. Preclinical research from The University of Texas MD Anderson Cancer Center finds that although glioblastoma stem cells (GSCs) can be targeted by natural killer (NK) cells, they are able to evade immune attack by...
Stroke is an abrupt interruption of constant blood flow to the brain that causes loss of neurological function, there are 3 types: a blocked artery (ischemic stroke) or leaking or bursting of a blood vessel (hemorrhagic stroke) and transient ischemic attack (TIA also known as a mini stroke ). Different factors can lead to a...
